Expression of CD20 in B Cell Precursor Acute Lymphoblastic Leukemia

Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia.

CD20 expression is associated with inferior survival in adults with acute lymphoblastic leukemia (ALL). We analyzed the prognostic impact of CD20 expression in 353 children with B-cell precursor ALL treated in 3 consecutive St Jude Total Therapy studies. CD20 expression (> 20%) was found in 169 patients (48%) and was more frequent in patients between 1 and 10 years of age than in those younger ...

Evaluation of FOXP1 gene expression in pediatric B-cell precursor acute lymphoblastic leukemia patients at remission induction therapy

Background: Transcription factors (TFs) play a key role in the development, therapy, and relapse of B-cell malignancies, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Given the essential function of Forkhead box protein P1 (FOXP1) transcription factor in the early development of B-cells, this study was designed to evaluate FOXP1 gene expression levels in pediatric BCP-ALL pat...

CD20 expression sub-stratifies standard-risk patients with B cell precursor acute lymphoblastic leukemia

Patients with standard-risk adult acute lymphoblastic leukemia (ALL) treated with chemotherapy do not have satisfactory outcomes. To more precisely classify ALL patients and optimize treatment, we re-evaluated the risk stratification system by examining CD20 expression and other classic risk factors at diagnosis. We retrospectively analyzed response to induction chemotherapy of 217 consecutive ...

Prognostic relevance of CD20 in adult B-cell precursor acute lymphoblastic leukemia.

Blood. 2007;110(4):1092-7. 10. Palandri F, Ottaviani E, Salmi F, Catani L, Polverelli N, Fiacchini M, et al. JAK2V617F mutation in essential thrombocythemia: correlation with clinical characteristics, responce to therapy and long-term out come in a cohort of 275 patients. Leuk Lymphoma 2009;50(2):247-53. 11. Finazzi G, Rambaldi A, Guerini V, Carobbo A, Barbui T. Risk of thrombosis in patients w...

CD20 has no prognostic significance in children with precursor B-cell acute lymphoblastic leukemia.